chair(s): heli harvala and maël bessaud
welcome

nic stonehouse (university of leeds, uk)

09:00 - 09:15
keynote presentation: seroepidemiology of enteroviruses: opportunities and challenges

marga pons-salort (imperial college london, uk)

09:15 - 10:00
offered paper: re-emergence of enterovirus d68 in europe after easing the covid-19 lockdown in 2021

kim benschop (national institute for public health and the environment, netherlands)

10:00 - 10:15
offered paper: human parechoviruses (hpev) infections can range from asymptomatic to life threatening, affecting mainly children. since the absence of a systematic hpev surveillance, it is difficult to estimate hpev-burden in europe.

laura bubba (european non-polio enterovirus network, italy)

10:15 - 10:30
break

10:30 - 11:00
offered paper: environmental surveillance for poliovirus in the uk between 2017-2022. recurrent isolation of type 1, 2 and 3 vaccine-like polioviruses

thomas wilton (national institute for biological standards and control, uk)

11:00 - 11:15
offered paper: rapid, direct sequencing of poliovirus from stool samples for routine afp surveillance in the democratic republic of the congo

alex shaw (imperial college london, uk)

11:15 - 11:30
offered paper: implementing world health organization (who) global action plan iii containment safeguards for united states (u.s.) poliovirus type 2 laboratories

christy ottendorfer (centers for disease control and prevention, usa)

11:30 - 11:45
offered paper: comparison of evolutionary trajectories of sabin 2 and nopv2 polio vaccines

sarah carlyle (national institute for biological standards and control, uk)

11:45 - 12:00
offered paper: impact and effectiveness of novel type 2 oral poliovirus vaccine during emergency use listing

laura cooper (imperial college london, uk)

12:00 - 12:15

lunch, networking and poster viewing

12:15 - 13:45

monday 06 june, afternoon

session 2: translation and replication

chair(s): toby tuthill and bert semler
keynote presentation: early events during enterovirus replication

raul andino (the university of california, san francisco medical center, usa)

13:45 - 14:30
offered paper: hsp70 cellular chaperones associate with rhinovirus non-structural proteins in infected cells and are important for the replication of the virus

aurélie mousnier (queen’s university belfast, uk)

14:30 - 14:45
offered paper: human-based models to study genotype dependent infection of parechovirus a

inés garcía rodríguez (university of amsterdam, netherlands)

14:45 - 15:00
offered paper: development of a replicon-based strand-specific qpcr assay to investigate fmdv genome replication

samuel dobson (university of leeds, uk)

15:00 - 15:15
offered paper: hepatitis a virus re-wires lipid metabolism to promote very-long chain fatty acid (vlcfa) synthesis required for viral rna replication

tomoyuki shiota (foundation of biomedical research and innovation at kobe, japan)

15:15 - 15:30
break

15:30 - 16:15
keynote presentation: illuminating picornavirus replication and virus-host interactions

frank van kuppeveld (utrecht university, netherlands)

16:15 - 17:00
offered paper: the involvement of packaging signals and the poly-c tract in foot-and-mouth disease virus packaging

chris neil (the pirbright institute, uk)

17:00 - 17:15
offered paper: the upstream orfs in picornaviruses: where, how and why?

valeria lulla (university of cambridge, uk)

17:15 - 17:30
offered paper: sexual rna replication among picornaviruses

david barton (university of colorado anschutz medical campus, usa)

17:30 - 17:45

dinner

18:15 - 20:00

poster session 1

20:00 - 22:00

tuesday 07 june, morning

session 3: virus entry and structure

chair(s): nicola stonehouse and pranav shah
keynote presentation: enterovirus stability and uncoating

varpu marjomäki (university of jyväskylä, finland)

09:00 - 09:45
offered paper: characterization of cross-neutralizing antibodies to poliovirus serotypes 1, 2, and 3

andrew charnseky (the pennsylvania state university, usa)

09:45 - 10:00
offered paper: enterovirus genome delivery

pavel plevka (masaryk university, czech republic)

10:00 - 10:15
offered paper: membrane interactions and uncoating of aichi virus, a picornavirus that lacks a vp4

james kelly (the pirbright institute, uk)

10:15 - 10:30
break

10:30 - 11:00
offered paper: chemical evolution of rhinovirus identifies capsid-destabilizing mutations driving low ph-independent genome uncoating

urs greber (university of zurich, switzerland)

11:00 - 11:15
offered paper: characterising the mechanism of enterovirus vp0 maturation cleavage

natalie kingston (university of leeds, uk)

11:15 - 11:30
offered paper: mechanistic insights into the anti-enteroviral activity of fluoxetine

daniel hurdiss (utrecht university, netherlands)

11:30 - 11:45
offered paper: using cryo-electron microscopy to understand aphthovirus replication

pui yiu audrey lai (university of oxford, uk)

11:45 - 12:00
late breaking abstracts

12:00 - 12:30

lunch, networking and poster viewing

12:30 - 14:00

tuesday 07 june, afternoon

session 4: evolution and diversity

chair(s): peter simmonds and rosa pinto
keynote presentation: the evolution of hav from animal reservoirs

jan felix drexler (german center for infection research, germany)

14:00 - 14:45
offered paper: classification and taxonomy of the picornaviridae: new species, genera and subfamilies

nick knowles (the pirbright institute, uk)

14:45 - 15:00
offered paper: evolution of nidoviral polymerases via key adaptations of the picornaviral polymerase active site

olve peersen (colorado state university, usa)

15:00 - 15:15
offered paper: demonstration of co-infection and trans-encapsidation of viral rna in vitro using epitope-tagged foot-and-mouth disease viruses.

kay childs (the pirbright institute, uk)

15:15 - 15:30
break

15:30 - 16:00
offered paper: molecular evolution of immunodeficiency-associated vdpv type 2 case from argentina

cristina lema (instituto nacional de enfermedades infecciosas, argentina)

16:00 - 16:15
offered paper: insights into picornavirus biology and evolution from deep mutational scanning analyses

ron geller (university of valència-csic, spain)

16:15 - 16:30
late breaking abstracts

16:30 - 17:15
sabin lecture

sir dave stuart (university of oxford, uk)

17:15 - 18:15

dinner

18:30 - 20:00

poster session 2

20:00 - 22:00

wednesday 08 june, morning

session 5: virus-host interactions and immune response

chair(s): david barton and laurent andreoletti
keynote presentation: foot-and-mouth disease virus carriers: virus persistence in individuals and populations

bryan charleston (pirbright institute, uk)

09:00 - 09:45
offered paper: a global understanding of how picornavirus capsids escape antibody neutralization

beatriz Álvarez rodríguez (university of valència-csic, spain)

09:45 - 10:00
offered paper: a picornavirus that retargets rsk kinases to phosphorylate new substrates

belén lizcano perret (uclouvain - de duve institute, belgium)

10:00 - 10:15
offered paper: structural analysis of the bovine antibody repertoire: contributions of the heavy and light to antigenic recognition

john clarke (university of oxford, uk)

10:15 - 10:30
break

10:30 - 11:00
offered paper: hav egress through the apical and basolateral membranes is controlled by the differential use of the hepatocyte traffic network

rosa pinto (university of barcelona, spain)

11:00 - 11:15
offered paper: heparan sulfate binding mediates enterovirus a71 virulence in immunosuppressed mice

han kang tee (université de genève, switzerland)

11:15 - 11:30
offered paper: primate interferon stimulated genes encode potent foot-and-mouth disease virus restriction factors

soumendu chakravarti (the pirbright institute, uk)

11:30 - 11:45
offered paper: structural and functional repurposing of human proteins apparently acquired by picornaviruses in their 2a locus

eleonore von castelmur (linkoping university, sweden)

11:45 - 12:00

lunch, networking and poster viewing

12:00 - 13:00

wednesday 08 june, afternoon

session 6: pathogenesis

chair(s): sisko tauriainen and graham belsham
keynote presentation: organoid models for human entero- and parechoviruses

katja wolthers (amsterdam umc, netherlands)

13:00 - 13:45
offered paper: early emergence and maintenance of major 5' terminally deleted viral rna forms are associated with the development of acute and persistent cvb3/28 infections in mouse

domitille callon (university of reims, france)

13:45 - 14:00
offered paper: pathogenesis linked to proteinase 2a activity during persistent cardiac infection by enteroviruses

alexis bouin (university of california irvine, usa)

14:00 - 14:15
offered paper: unravelling the role of immune cells in the viremia of enterovirus-d68

brigitta laksono (erasmus mc, netherlands)

14:15 - 14:30

visit to skipton castle

14:30 - 18:30

conference dinner and entertainment

20:00 - 23:00

thursday 09 june, morning

session 7: treatment and prevention

chair(s): david rowlands and kimberly benschop
keynote presentation: facing the oral poliovirus vaccine paradox

cara burns (centers for disease control and prevention, usa)

09:45 - 10:30
offered paper: initial use of type 2 novel opv for immunisation campaigns in several countries

javier martin (national institute for biological standards and control, uk)

10:30 - 10:45
break

10:45 - 11:15
offered paper: protease-free production of poliovirus vlps using pichia pastoris: insights into particle formation and potential vaccine candidates

lee sherry (university of leeds, uk)

11:15 - 11:30
offered paper: design of stable enterovirus a71-c4 virus like particles (vlps) as a potential approach to vaccine development

agnieszka martyna (national institute for biological standards and control, uk)

11:30 - 11:45
offered paper: immunogenicity of polio vlps formulated with adjuvants

andrew macadam (national institute for biological standards and control, uk)

11:45 - 12:00

lunch

12:00 - 13:15

thursday 09 june, afternoon

arrival reception and bbq

chair(s): heli harvala and maël bessaud

welcome

keynote presentation: seroepidemiology of enteroviruses: opportunities and challenges

offered paper: re-emergence of enterovirus d68 in europe after easing the covid-19 lockdown in 2021

offered paper: human parechoviruses (hpev) infections can range from asymptomatic to life threatening, affecting mainly children. since the absence of a systematic hpev surveillance, it is difficult to estimate hpev-burden in europe.

break

offered paper: environmental surveillance for poliovirus in the uk between 2017-2022. recurrent isolation of type 1, 2 and 3 vaccine-like polioviruses

offered paper: rapid, direct sequencing of poliovirus from stool samples for routine afp surveillance in the democratic republic of the congo

offered paper: implementing world health organization (who) global action plan iii containment safeguards for united states (u.s.) poliovirus type 2 laboratories

offered paper: comparison of evolutionary trajectories of sabin 2 and nopv2 polio vaccines

offered paper: impact and effectiveness of novel type 2 oral poliovirus vaccine during emergency use listing

lunch, networking and poster viewing

chair(s): toby tuthill and bert semler

keynote presentation: early events during enterovirus replication

offered paper: hsp70 cellular chaperones associate with rhinovirus non-structural proteins in infected cells and are important for the replication of the virus

offered paper: human-based models to study genotype dependent infection of parechovirus a

offered paper: development of a replicon-based strand-specific qpcr assay to investigate fmdv genome replication

offered paper: hepatitis a virus re-wires lipid metabolism to promote very-long chain fatty acid (vlcfa) synthesis required for viral rna replication

break

keynote presentation: illuminating picornavirus replication and virus-host interactions

offered paper: the involvement of packaging signals and the poly-c tract in foot-and-mouth disease virus packaging

offered paper: the upstream orfs in picornaviruses: where, how and why?

offered paper: sexual rna replication among picornaviruses

dinner

poster session 1

chair(s): nicola stonehouse and pranav shah

keynote presentation: enterovirus stability and uncoating

offered paper: characterization of cross-neutralizing antibodies to poliovirus serotypes 1, 2, and 3

offered paper: enterovirus genome delivery

offered paper: membrane interactions and uncoating of aichi virus, a picornavirus that lacks a vp4

break

offered paper: chemical evolution of rhinovirus identifies capsid-destabilizing mutations driving low ph-independent genome uncoating

offered paper: characterising the mechanism of enterovirus vp0 maturation cleavage

offered paper: mechanistic insights into the anti-enteroviral activity of fluoxetine

offered paper: using cryo-electron microscopy to understand aphthovirus replication

late breaking abstracts

lunch, networking and poster viewing

chair(s): peter simmonds and rosa pinto

keynote presentation: the evolution of hav from animal reservoirs

offered paper: classification and taxonomy of the picornaviridae: new species, genera and subfamilies

offered paper: evolution of nidoviral polymerases via key adaptations of the picornaviral polymerase active site

offered paper: demonstration of co-infection and trans-encapsidation of viral rna in vitro using epitope-tagged foot-and-mouth disease viruses.

break

offered paper: molecular evolution of immunodeficiency-associated vdpv type 2 case from argentina

offered paper: insights into picornavirus biology and evolution from deep mutational scanning analyses

late breaking abstracts

sabin lecture

dinner

poster session 2

chair(s): david barton and laurent andreoletti

keynote presentation: foot-and-mouth disease virus carriers: virus persistence in individuals and populations

offered paper: a global understanding of how picornavirus capsids escape antibody neutralization

offered paper: a picornavirus that retargets rsk kinases to phosphorylate new substrates

offered paper: structural analysis of the bovine antibody repertoire: contributions of the heavy and light to antigenic recognition

break

offered paper: hav egress through the apical and basolateral membranes is controlled by the differential use of the hepatocyte traffic network

offered paper: heparan sulfate binding mediates enterovirus a71 virulence in immunosuppressed mice

offered paper: primate interferon stimulated genes encode potent foot-and-mouth disease virus restriction factors

offered paper: structural and functional repurposing of human proteins apparently acquired by picornaviruses in their 2a locus

lunch, networking and poster viewing

chair(s): sisko tauriainen and graham belsham

keynote presentation: organoid models for human entero- and parechoviruses

offered paper: early emergence and maintenance of major 5' terminally deleted viral rna forms are associated with the development of acute and persistent cvb3/28 infections in mouse

offered paper: pathogenesis linked to proteinase 2a activity during persistent cardiac infection by enteroviruses

offered paper: unravelling the role of immune cells in the viremia of enterovirus-d68

visit to skipton castle

conference dinner and entertainment

chair(s): david rowlands and kimberly benschop

keynote presentation: facing the oral poliovirus vaccine paradox

offered paper: initial use of type 2 novel opv for immunisation campaigns in several countries

break

offered paper: protease-free production of poliovirus vlps using pichia pastoris: insights into particle formation and potential vaccine candidates

offered paper: design of stable enterovirus a71-c4 virus like particles (vlps) as a potential approach to vaccine development

offered paper: immunogenicity of polio vlps formulated with adjuvants

lunch

offered paper: assembly of d-antigenic poliovirus vlps in a mammalian cell-free translation system

offered paper: polyphenols epigallocatechin gallate and resveratrol, and polyphenol-functionalized nanoparticles prevent enterovirus infection through clustering and stabilization of the viruses

keynote presentation: rhinoviruses in asthma & copd - importance and treatment options

meeting summary and close